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KMID : 1022220150040020132
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Clinical Nutrition Research
2015 Volume.4 No. 2 p.132 ~ p.136
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Nutrition Therapy for Mitochondrial Neurogastrointestinal Encephalopathy with Homozygous Mutation of the TYMP Gene
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Wang Jing
Chen Wei
Wang Fang
Wu Dong
Qian Jia Ming
Kang Jun Ren
Li Hai Long
Ma En Ling
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Abstract
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Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is characterized by significant gastrointestinal dysmotility. Early and long-term nutritional therapy is highly recommended. We report a case of MNGIE in a patient who was undergoing long-term nutrition therapy. The patient was diagnosed with a serious symptom of fatty liver and hyperlipidemia complications, along with homozygous mutation of the thymidine phosphorylase (TYMP) gene (c.217G > A). To our knowledge, this is the first report of such a case. Herein, we describe preventive measures for the aforementioned complications and mitochondrial disease-specific nutritional therapy.
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KEYWORD
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Mitochondrial neurogastrointestinal encephalopathy syndrome, TYMP gene, Nutrition therapy, Complications
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